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A Simple Saliva-Based Test for Detecting Antibodies to Human Immunodeficiency Virus
This study was performed to determine the feasibility of using saliva as a diagnostic medium for the detection of antibodies to human immunodeficiency virus type 1 (HIV-1) and HIV-2 under nonlaboratory conditions and to evaluate the performance characteristics of such a test.
Saliva test strips.
The test strips used for this study were lateral-flow immunochromatography devices. Two synthetic peptides representing highly conserved regions of viral transmembrane glycoproteins gp41 and gp36 were used to capture antibodies to HIV-1 and HIV-2, respectively. These two antigens are identical to those used in similar test strips designed for use with serum and whole blood.